Samaneh Hosseini Ph.D.
Department of Stem Cells and Developmental Biology
Samaneh Hosseini received her Bachelor of Science degree in Biology and, Master of Science in Biophysics. She received her PhD in Nanobiotechnology from Tarbiat Modares University where she worked on the design of a natural peptide motif sequence to promote biomineralization and hard tissue regeneration. She joined Prof. Hojatollah Vali’s Lab at McGill University and she got adapted with the nanoscale visualization techniques (TEM, SEM, Cryo-TEM and AFM) for studying biomineralization and nanocrystal formation. She has developed great interest on biomimetics, nanostructures and delivery systems for tissue regeneration. She performed her Post-doctoral fellowship on cell-based tissue engineering for hard tissue regeneration in bone and cartilage group at Royan Institute where she currently is an Assistant Professor.
The development of novel tissue constructs for the efficient tissue regeneration is the overall objective of our research group. We employ nanobiotechnology, biomimetics and engineering techniques to improve cell-substrate interactions for enhanced biological activity. The current challenge in our group is to be able to accurately control delivery of bioactive molecules for stem cell differentiation and therapy. The development of nanobiosensors that can rapidly diagnose diseases is another ongoing research projects in our group. Accordingly, some of the research topics include:
- Biomimetic peptides
- Targeted cell & drug delivery
- Cell-cell and cell-biomaterial interactions.
- 3D printing
- Fabrication of 3D and 2D biocompatible scaffold for tissue engineering, particularly hard tissues such as bone, cartilage, teeth, disk
Niloofar Kalantari, MSc (Alumni)
Project Title: Development of a bioink derived from decellularized bone with calcium phosphate for bioprinting of 3D-scaffold in bone tissue
Sara Farahi, PhD (Alumni)
Project Title: Immunogenicity Analysis of Induced Pluripotent Stem Cell Produced by Pluripotency Vector and Small Molecules
Maryam Hatami, MSc Student
Project Title: Characterization of hydroxyapatite/gelatin scaffold containing a biomineralizing peptide in Segmental defect in rat model
Yalda Alibeigian, MSc Student
Project Title: Characterization of Decellularized-bone Extracellular Matrix/Calcium Phosphate Cement Scaffold in Calvarial Defect in Rat Model
Amin Ebrahimi, PhD Student
Project Title: Development of bio-printed bone construct to promote osteogenesis-angiogenesis coupling process
Farzaneh Mirzaeian, PhD Student
Project Title: The effect of MSC-derived extracellular vesicles enriched by miR-93 on osteoarthritis treatment in rat model
- Selected Publications:
- Nasiri N, Hosseini S, Reihani-Sabet F, Baghaban Eslaminejad M. Targeted Mesenchymal Stem Cell Therapy Equipped with Cell-tissue Nanomatchmaker Stops Osteoarthritis Progression, Scientific reports,
- Esmaeili A, Alini M, Baghaban Eslaminejad MR, Hosseini S. Engineering Strategies for Customizing Extracellular Vesicle Uptake in a Therapeutic Context, Stem Cell Research and Therapy, 2022,
- Farahi S, Hosseini S, Hashemi S, Ghanbarian H, Salehi M, Hosseini S. The Use of Trichostatin A during Pluripotent Stem Cell Generation Does Not Affect MHC Expression Level, Stem Cells International, 2022, 2022: 1-12.
- Hosseinzadeh M, Kamali A, Hosseini S, Baghaban Eslaminejad MR. Higher Chondrogenic Potential of Extracellular Vesicles Derived from Mesenchymal Stem Cells Compared to Chondrocytes-EVs in Vitro, BioMed Research International, 2021, 2021: 1-12.
- Esmaeili A, Hosseini S, Baghaban Eslaminejad MR. Engineered-extracellular vesicles as an optimistic tool for microRNA delivery for osteoarthritis treatment, Cellular and Molecular Life Sciences, 2020, 78 (1): 79-91.
- Ghorbaninejad M, Khademi-Shirvan M, Hosseini S, Eslaminejad MB, Epidrugs: novel epigenetic regulators that open a new window for targeting osteoblast differentiation, Stem Cell Research and Therapy, 2020, 11 (1): 1-14.
- Nasiri N, Hosseini S, Alini M, Khademhosseini A, Baghaban Eslaminejad MR. Targeted cell delivery for articular cartilage regeneration and osteoarthritis treatment, Drug Discovery Today, 2019, 24 (11), 2212-2224.
- Hosseini S, Naderi-Manesh H, Vali H, Baghaban Eslaminejad MR, Sayahpour FA, Faghihi S. Contribution of osteocalcin mimetic peptide enhances osteogenic activity and extracellular matrix mineralization of human osteoblast-like cells, Colloid and Surface B. 2018, 173: 662-671.
- Taghiyar L, Hesaraki M, Azam Sayahpour F, Satarian L, Hosseini S, Aghdami N, Baghaban Eslaminejad MR, Msh homeobox 1 (Msx1)- and Msx2-overexpressing bone marrow-derived mesenchymal stem cells resemble blastema cells and enhance regeneration in mice, Journal of Biological Chemistry, 2017, 292(25):10520-10533.
A position for a talented and motivated Ph.D. student is open in my group.