Samaneh Hosseini Ph.D.

Department of Stem Cells and Developmental Biology

Assistant professor

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Samaneh Hosseini received her Bachelor of Science degree in Biology and, Master of Science in Biophysics. She received her PhD in Nanobiotechnology from Tarbiat Modares University where she worked on the design of a natural peptide motif sequence to promote biomineralization and hard tissue regeneration. She joined Prof. Hojatollah Vali’s Lab at McGill University and she got adapted with the nanoscale visualization techniques (TEM, SEM, Cryo-TEM and AFM) for studying biomineralization and nanocrystal formation. She has developed great interest on biomimetics, nanostructures and delivery systems for tissue regeneration. She performed her Post-doctoral fellowship on cell-based tissue engineering for hard tissue regeneration in bone and cartilage group at Royan Institute where she currently is an Assistant Professor.

The development of novel tissue constructs for the efficient tissue regeneration is the overall objective of our research group. We employ nanobiotechnology, biomimetics and engineering techniques to improve cell-substrate interactions for enhanced biological activity. The current challenge in our group is to be able to accurately control delivery of bioactive molecules for stem cell differentiation and therapy. The development of nanobiosensors that can rapidly diagnose diseases is another ongoing research projects in our group. Accordingly, some of the research topics include:

  • Biomineralization
  • Biomimetic peptides
  • Targeted cell & drug delivery
  • Cell-cell and cell-biomaterial interactions.
  • 3D printing
  • Fabrication of 3D and 2D biocompatible scaffold for tissue engineering, particularly hard tissues such as bone, cartilage, teeth, disk
  • Nanobiomaterials

Niloofar Kalantari, MSC Student

Selected Publications:

Journal Papers:

  • Hosseini S, Naderi-Manesh H, Mountassif D, Cerruti M, Vali H, Faghihi S. C-terminal amidation of an osteocalcin-derived peptide promotes hydroxyapatite crystallization. Journal of biological chemistry, 2013, 288: 7885-7893.
  • Hosseini S, Naderi-Manesh H, Vali H, Faghihi S. Improved surface bioactivity of stainless steel substrates using osteocalcin mimetic peptide. Material chemistry and physics, 2014, 143: 1364-1371.
  • Taghiyar L, Hesaraki M, Sayahpour FA, Satarian L, Hosseini S, Aghdami N, Baghaban Eslaminejad MR, Msh homeobox 1 (Msx1)- and Msx2-overexpressing bone marrow-derived mesenchymal stem cells resemble blastema cells and enhance regeneration in mice, Journal of Biological Chemistry, 2017, 292(25):10520-10533
  • Oryan A, Baghaban Eslaminejad MR, Kamali A, Hosseini S, Sayahpour FA, Baharvand H, Synergistic effect of strontium, bioactive glass and nano-hydroxyapatite promotes bone regeneration of critical-sized radial bone defects, Journal of Biomedical Materials Research Part B,
  • Taghiyar L, Hosseini S, Hesaraki M, Sayahpour FA, Aghdami N, Baghaban Eslaminejad MR, Isolation, characterization and osteogenic potential of mouse digit tip blastema cells in comparison with bone marrow-derived mesenchymal stem cells in vitro, Cell Journal, 2018, 19 (4): 585-598.

 

Chapter Books:

  • Hosseini S, Baghaban Eslaminejad MR, “Mesenchymal Stem cells: An Optimistic Cell Source in Tissue Engineering for Bone Regeneration” in the book “Cartilage and Bone Regeneration (Stem Cells in Clinical Application)” Edited by Phuc Van Pham, 2017, Springer (Humana Press).
  • Hosseini S, Jahangir Sh, Baghaban Eslaminejad MR, “Tooth tissue engineering” in the book” Biomaterials for Oral and Dental Tissue Engineering, Materials and Strategies” Edited by Lobat Tayebi and Keyvan Moharamzadeh, 2017, Elsevier.
  • Hosseini S, Shamekhi MA, Jahangir Sh, Bagheri F, Baghaban Eslaminejad MR, “The robust potential of mesenchymal stem cell-loaded constructs for hard tissue regeneration after cancer removal” in the book “Advances in Experimental Medicine and Biology” Edited by Phuc Van Pham, 2018, Springer (Humana Press).
  • Hosseini S, Bagheri F, Shamekhi MA, Baghaban Eslaminejad MR, “Polymeric Scaffolds for MSC-based Cartilage Tissue Engineering” in the book “Encyclopedia of polymer application”. 2018, Taylor & Francis.