Sharif Moradi Ph.D.

Department of Stem Cells and Developmental Biology

Assistant professor

Email: sharif.moradi@royaninstitute.org

Phone: +98 21 23562512

CV: Sharif Moradi CV 2018

Sharif Moradi got his B.Sc in Biology from Khwarizmi University of Tehran in 2008 and his M.Sc in Cell & Molecular Biology from Tehran University in 2010. He then joined Royan Institute as a PhD student of Developmental Biology and worked in Prof. Hossein Baharvand’s lab on the expression and functional significance of microRNAs in ES and iPS cells. During his PhD, he moved to Prof. Thomas Braun’s lab at Germany’s Max-Planck Institute (Bad Nauheim) to complete the remaining parts of his PhD thesis (2014-2015). He got his PhD in 2017 and is now a PI at Royan Institute, with his research being focused on non-coding RNAs including microRNAs and lncRNAs in immortal cells (ES and iPS cells as well as cancer cells). He is particularly interested in developing diagnostic tools and therapeutic strategies using non-coding RNAs.

Embryonic stem cell (ESC) derivation and maintenance

Pre-implantation embryogenesis

Cell fate reprogramming (iPS and transdifferentiation)

MicroRNAs in pluripotent stem cells

lncRNAs in pluripotent stem cells

Targeting the tumorigenic potential of pluripotent stem cells

MicroRNAs in cancer cells

MSc Student:

Samira Soori, MSc student

Project: Functional analysis of microRNAs during embryonic stem cell derivation

Rana Bagheri, MSc student

Project: Elimination of residual pluripotent cells from differentiated cell populations using small molecules

Selected Publications:

  1. Sharif Moradi, Thomas Braun, Hossein Baharvand. miR-302b-3p promotes self-renewal properties in LIF-withdrawn embryonic stem cells. Cell Journal (Yakhteh), 2018
  2. Sharif Moradi, Ali Sharifi-Zarchi, Amirhossein Ahmadi, Sepideh Mollamohammadi, Alexander Stubenvoll, Stefan Günther, Ghasem Hosseini Salekdeh, Sassan Asgari, Thomas Braun, Hossein Baharvand. Small RNA Sequencing Reveals Dlk1-Dio3 Locus-Embedded MicroRNAs as Major Drivers of Ground State Pluripotency. Stem Cell Reports, 2017
  3. Ebrahim Shahbazi, Sharif Moradi, Shiva Nemati, Leila Satarian, Mohsen Basiri, Hamid Gourabi, Narges Zare Mehrjardi, Patrick Günther, Angelika Lampert, Kristian Händler, Firuze Fulya Hatay, Diana Schmidt, Marek Molcanyi, Jürgen Hescheler, Joachim L. Schultze, Tomo Saric, Hossein Baharvand. Conversion of Human Fibroblasts to Stably Self-Renewing Neural Stem Cells with a Single Zinc-Finger Transcription Factor. Stem Cell Reports, 2016
  4. Sharif Moradi, Sassan Asgari, Hossein Baharvand. Concise review: harmonies played by microRNAs in cell fate reprogramming. Stem Cells, 2014
  5. Seyedeh-Nafiseh Hassani, Mehdi Totonchi, Ali Sharifi-Zarchi, Sepideh Mollamohammadi, Mohammad Pakzad, Sharif Moradi, Azam Samadian, Najmehsadat Masoudi, Shahab Mirshahvaladi, Ali Farrokhi, Boris Greber, Marcos J. Araúzo-Bravo, Davood Sabour, Mehdi Sadeghi, Ghasem Hosseini Salekdeh, Hamid Gourabi, Hans R. Schöler, Hossein Baharvand. Inhibition of TGFβ Signaling Promotes Ground State Pluripotency. Stem Cell Reviews and Reports, 2014
  6. Sharif Moradi, Hossein Baharvand. Induced pluripotent stem cells, from generation to application. Tehran University Medical Journal, 2014

Dr. Moradi’s lab is focused on the expression and functional roles of non-coding RNAs in immortal cells (i.e. pluripotent and cancer cells) as well as on developing diagnostic tools and therapeutic strategies using non-coding RNAs (e.g. miRNAs, siRNAs, and lncRNAs). We are accepting MSc and PhD students interested in these interesting areas of research.

Interested and talented students are invited to send their requests along with their CV to sharif.moradi@gmail.com.