تصویر

Samaneh Hosseini    Ph.D
Cell Engineering
Assistant professor

Email:s.hosseini@royan-rc.ac.ir
Tel:+98 2123562706
Fax:
CV:Samaneh Hosseini

Samaneh Hosseini received her Bachelor of Science degree in Biology and, Master of Science in Biophysics. She received her PhD in Nanobiotechnology from Tarbiat Modares University where she worked on the design of a natural peptide motif sequence to promote biomineralization and hard tissue regeneration. She joined Prof. Hojatollah Vali’s Lab at McGill University and she got adapted with the nanoscale visualization techniques (TEM, SEM, Cryo-TEM and AFM) for studying biomineralization and nanocrystal formation. She has developed great interest on biomimetics, nanostructures and delivery systems for tissue regeneration. She performed her Post-doctoral fellowship on cell-based tissue engineering for hard tissue regeneration in bone and cartilage group at Royan Institute where she currently is an Assistant Professor.

The development of novel tissue constructs for the efficient tissue regeneration is the overall objective of our research group. We employ nanobiotechnology, biomimetics and engineering techniques to improve cell-substrate interactions for enhanced biological activity. The current challenge in our group is to be able to accurately control delivery of bioactive molecules for stem cell differentiation and therapy. The development of nanobiosensors that can rapidly diagnose diseases is another ongoing research projects in our group. Accordingly, some of the research topics include: Biomineralization Biomimetic peptides Targeted cell & drug delivery Cell-cell and cell-biomaterial interactions. 3D printing Fabrication of 3D and 2D biocompatible scaffold for tissue engineering, particularly hard tissues such as bone, cartilage, teeth, disk Nanobiomaterials

Esmaeili A, Hosseini S, Baghaban Eslaminejad MR, Co-culture engineering: a promising strategy for production of engineered extracellular vesicle for osteoarthritis treatment, Cell Communication and Signalling, 2024, 22 (1), 29 Hosseinzadeh M, Kamali A, Hosseini S, Baghaban Eslaminejad MR. Extracellular Vesicles Derived from Chondrocyte/MSC Co-Culture Alleviate Osteoarthritis in Rat, Cell and Tissue Research, 2023, 394 (1), 145-162 Ghorbaninejad M, Khademi-Shirvan M, Hosseini S, Meyfour A, ShahHosseini M, Eslaminejad MB, Effective Role of Curcumin on Expression Regulation of EZH2 Histone Methyltransferase as a Dynamic Epigenetic Factor in Osteogenic Differentiation of Human Mesenchymal Stem Cells, Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms, 2023, 1866: 194903 Esmaeili A, Hosseini S, Kamali A, Hosseinzadeh M, Shekari F, Baghaban Eslaminejad MR, Co-aggregation of MSC/Chondrocyte in a Dynamic 3D Culture Elevates the Therapeutic Effect of Secreted Extracellular Vesicles on Osteoarthritis in a Rat Model, Scientific reports, 12: 1-15. Mohseni M, Shokrollahi P, Shokrolahi F, Hosseini S, Taghiyar L, Kamali A. Dexamethasone Loaded injectable, Self-healing Hydrogel Microspheres Based on UPy-Functionalized Gelatin/ZnHAp Physical Network Promotes Bone Regeneration, International Journal of Pharmaceutics, 2022, 626: 122196. Nasiri N, Hosseini S, Reihani-Sabet F, Baghaban Eslaminejad M. Targeted Mesenchymal Stem Cell Therapy Equipped with Cell-tissue Nanomatchmaker Stops Osteoarthritis Progression, Scientific reports, Esmaeili A, Alini M, Baghaban Eslaminejad MR, Hosseini S. Engineering Strategies for Customizing Extracellular Vesicle Uptake in a Therapeutic Context, Stem Cell Research and Therapy, 2022, Esmaeili A, Hosseini S, Baghaban Eslaminejad MR. Engineered-extracellular vesicles as an optimistic tool for microRNA delivery for osteoarthritis treatment, Cellular and Molecular Life Sciences, 2020, 78 (1): 79-91. Ghorbaninejad M, Khademi-Shirvan M, Hosseini S, Eslaminejad MB, Epidrugs: novel epigenetic regulators that open a new window for targeting osteoblast differentiation, Stem Cell Research and Therapy, 2020, 11 (1): 1-14. Nasiri N, Hosseini S, Alini M, Khademhosseini A, Baghaban Eslaminejad MR. Targeted cell delivery for articular cartilage regeneration and osteoarthritis treatment, Drug Discovery Today, 2019, 24 (11), 2212-2224. Hosseini S, Naderi-Manesh H, Vali H, Baghaban Eslaminejad MR, Sayahpour FA, Faghihi S. Contribution of osteocalcin mimetic peptide enhances osteogenic activity and extracellular matrix mineralization of human osteoblast-like cells, Colloid and Surface B. 2018, 173: 662-671. Taghiyar L, Hesaraki M, Azam Sayahpour F, Satarian L, Hosseini S, Aghdami N, Baghaban Eslaminejad MR, Msh homeobox 1 (Msx1)- and Msx2-overexpressing bone marrow-derived mesenchymal stem cells resemble blastema cells and enhance regeneration in mice, Journal of Biological Chemistry, 2017, 292(25):10520-10533. Book: Cartilage: From Biology to Biofabrication, Edited by Hosseini S, Baghaban Eslaminejad MR, Springer Nature. 2023

A position for a talented and motivated Ph.D. student is open in my group.