تصویر

Samaneh Hosseini    Ph.D
Cell Engineering
Assistant professor

Email:s.hosseini@royan-rc.ac.ir
Tel:+98 2123562706
Fax:
CV:Samaneh Hosseini


Samaneh Hosseini received her Bachelor of Science degree in Biology and, Master of Science in Biophysics. She received her PhD in Nanobiotechnology from Tarbiat Modares University where she worked on the design of a natural peptide motif sequence to promote biomineralization and hard tissue regeneration. She joined Prof. Hojatollah Vali’s Lab at McGill University and she got adapted with the nanoscale visualization techniques (TEM, SEM, Cryo-TEM and AFM) for studying biomineralization and nanocrystal formation. She has developed great interest on biomimetics, nanostructures and delivery systems for tissue regeneration. She performed her Post-doctoral fellowship on cell-based tissue engineering for hard tissue regeneration in bone and cartilage group at Royan Institute where she currently is an Assistant Professor.

The development of novel tissue constructs for the efficient tissue regeneration is the overall objective of our research group. We employ nanobiotechnology, biomimetics and engineering techniques to improve cell-substrate interactions for enhanced biological activity. The current challenge in our group is to be able to accurately control delivery of bioactive molecules for stem cell differentiation and therapy. The development of nanobiosensors that can rapidly diagnose diseases is another ongoing research projects in our group. Accordingly, some of the research topics include:
- Biomineralization,
- Biomimetic peptides,
- Targeted cell & drug delivery,
- Cell-cell and cell-biomaterial interactions,
- Fabrication of 3D and 2D biocompatible scaffold for tissue engineering, particularly hard tissues such as bone, cartilage, teeth, disk.

Amin Ebrahimi- PhD Alumni.png
Amin Ebrahimi

PhD Alumni

Sadaf Lashgari.jpg
sadaf Lashgari

MSc Alumni

Saghi Ghafarzadeh.png
Saghi Ghafarzadeh

MSc Alumni

Amirali Judaki-MSC Alumni.jpg
Amirali Judaki

MSc Alumni

Pegah Shams- MSc Alumni.jpg
Pegah Shams

MSc Alumni

Maoumeh Kafi- MSc student.jpg
Maoumeh Kafi

MSc Students

Selected Papers:

- Ghorbaninejad M, Kamrani S, Ghorbaninejad Z, Hosseini S, Epigenetic Crosstalk in Bone and Cartilage Disorders: Emerging Role of Extracellular Vesicles, Biomedicine & Pharmacotherapy, 2025, 193, 118706.

- Ebrahimi Sadrabadi A, Arab S, Kamali A, Karimi S, Baghaban Eslaminejad MR, Hosseini S, Biphasic Bone-Mimicking Constructs Containing Silk Fibroin Peptide Enhanced Bone Regeneration in Segmental Defects in Rats, Biomaterials Advances, 2025, 214650.

- Ebrahimi F, Jalali H, Kalantari N, Ghanian MH, Hosseini S, Dual-Functional Decellularized Bone Scaffolds Embedded with PLGA–Linezolid Microparticles for Enhanced Bone Regeneration and Infection Control, BioMedical Engineering OnLine, 2025, 24 (1), 140.

- Jelodari S, Baei P, Halvaei M, Hosseinpour N, Sheykhhassan M, Hosseini S, Bioinspired 3D-Printing Strategies for Skeletal Tissue Regeneration; From Natural Architectures to Clinical Applications, Journal of Biomaterials Applications, 2025.

- Ebrahimi Sadrabadi A, Baei P, Baghaban Eslaminejad MR, Hosseini S. Toward functional bone bioprinting: Addressing the overlooked challenges of mechanical compliance, International Journal of Bioprinting, 2025, 025420425.

- Sedaghat A, Shokrolahi F, Yeganeh H, Shokrolahi P, Hosseini S, Injectable Gellan Gum Hydrogel with PLGA-LDH Microspheres for Controlled Alendronate Release and Bone Regeneration, International Journal of Biological Macromolecules, 2025.

- Leisi Mehrabani F, Alibeigian Y, Baghaban Eslaminejad MR, Hosseini S, Mechanical Harvesting of Cell Sheets: An Efficient Approach for Bone and Cartilage Tissue Engineering, Stem Cell Research & Therapy, 2025

- Esmaeili A, Hosseini S, Baghaban Eslaminejad MR, The Biocorona and its Considerable Potential in Extracellular Vesicle Engineering for Clinical Applications, Biomedicine and Pharmacotherapy, 2025

- Alibeigian Y, Kalantari N, Ebrahimi Sadrabadi A, Kamali A, Raminfard S, Baghaban Eslaminejad MR, Hosseini S, Incorporation of Calcium Phosphate Cement into Decellularized Extracellular Matrix (CPC/dECM) Enhances its Mechanical and Bone Regenerative Properties, Colloid and Surface B: Biointerface, 2024.

- Esmaeili A, Hosseini S, Baghaban Eslaminejad MR, Co-culture engineering: a promising strategy for production of engineered extracellular vesicle for osteoarthritis treatment, Cell Communication and Signaling, 2024, 22 (1), 29

- Rabani Doost A, Shokrolahi F, Shokrollahi P, Barzin J, Hosseini S, Engineering antibacterial shrinkage‐free trinary PLGA‐b ased GBR membrane for bone regeneration, Polymers for Advanced Technologies, 2024, 35 (1), e6263

- Hosseinzadeh M, Kamali A, Hosseini S, Baghaban Eslaminejad MR. Extracellular Vesicles Derived from Chondrocyte/MSC Co-Culture Alleviate Osteoarthritis in Rat, Cell and Tissue Research, 2023, 394 (1), 145-162

- Ghorbaninejad M, Khademi-Shirvan M, Hosseini S, Meyfour A, ShahHosseini M, Eslaminejad MB, Effective Role of Curcumin on Expression Regulation of EZH2 Histone Methyltransferase as a Dynamic Epigenetic Factor in Osteogenic Differentiation of Human Mesenchymal Stem Cells, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2023, 1866: 194903

- Esmaeili A, Hosseini S, Kamali A, Hosseinzadeh M, Shekari F, Baghaban Eslaminejad MR, Co-aggregation of MSC/Chondrocyte in a Dynamic 3D Culture Elevates the Therapeutic Effect of Secreted Extracellular Vesicles on Osteoarthritis in a Rat Model, Scientific reports, 2022. 12: 1-15.

- Mohseni M, Shokrollahi P, Shokrolahi F, Hosseini S, Taghiyar L, Kamali A. Dexamethasone Loaded injectable, Self-healing Hydrogel Microspheres Based on UPyFunctionalized Gelatin/ZnHAp Physical Network Promotes Bone Regeneration, International Journal of Pharmaceutics, 2022, 626: 122196.

- Nasiri N, Hosseini S, Reihani-Sabet F, Baghaban Eslaminejad M. Targeted Mesenchymal Stem Cell Therapy Equipped with Cell-tissue Nanomatchmaker Stops Osteoarthritis Progression, Scientific reports, 2022. 12: 1-13.

- Esmaeili A, Alini M, Baghaban Eslaminejad MR, Hosseini S. Engineering Strategies for Customizing Extracellular Vesicle Uptake in a Therapeutic Context, Stem Cell Research and Therapy, 2022, 13: 129.

- Esmaeili A, Hosseini S, Baghaban Eslaminejad MR. Engineered-extracellular vesicles as an optimistic tool for microRNA delivery for osteoarthritis treatment, Cellular and Molecular Life Sciences, 2020, 78 (1): 79-91.

- Ghorbaninejad M, Khademi-Shirvan M, Hosseini S, Eslaminejad MB, Epidrugs: novel epigenetic regulators that open a new window for targeting osteoblast differentiation, Stem Cell Research and Therapy, 2020, 11 (1): 1-14.

- Nasiri N, Hosseini S, Alini M, Khademhosseini A, Baghaban Eslaminejad MR. Targeted cell delivery for articular cartilage regeneration and osteoarthritis treatment, Drug Discovery Today, 2019, 24 (11), 2212-2224.

- Hosseini S, Naderi-Manesh H, Vali H, Baghaban Eslaminejad MR, Sayahpour FA, Faghihi S. Contribution of osteocalcin mimetic peptide enhances osteogenic activity and extracellular matrix mineralization of human osteoblast-like cells, Colloid and Surface B. 2018, 173: 662-671.

- Kamali A, Oryan A, Hosseini S, Ghanian MH, Alizadeh M, Baghaban Eslaminejad MR, Baharvand H. Cannabidiol-loaded microspheres incorporated into osteoconductive scaffold enhance mesenchymal stem cell recruitment and regeneration of critical-sized bone defects, Material Science and Engineering C. 2019; 101: 64-75.

- Taghiyar L, Hosseini S, Safari F, Bagheri F, Fani N, Stoddart M. J., Alini M, Baghaban Eslaminejad MR. New insight into functional limb regeneration: A to Z approaches, Journal of Tissue Engineering and Regenerative Medicine, 2018, 12(9): 1925-1943.

- Taghiyar L, Hesaraki M, Azam Sayahpour F, Satarian L, Hosseini S, Aghdami N, Baghaban Eslaminejad MR, Msh homeobox 1 (Msx1)- and Msx2-overexpressing bone marrow-derived mesenchymal stem cells resemble blastema cells and enhance regeneration in mice, Journal of Biological Chemistry, 2017, 292(25):10520-10533.

- Hosseini S, Naderi-Manesh H, Vali H, Faghihi S. Improved surface bioactivity of stainless steel substrates using osteocalcin mimetic peptide. Material chemistry and physics, 2014, 143: 1364-1371.

- Hosseini S, Naderi-Manesh H, Mountassif D, Cerruti M, Vali H, Faghihi S. C-terminal amidation of an osteocalcin-derived peptide promotes hydroxyapatite crystallization. Journal of biological chemistry, 2013, 288: 7885-7893.

 

Books and Book chapters: 

- Cartilage: From Biology to Biofabrication, Edited by Hosseini S, Baghaban Eslaminejad MR, Springer Nature. 2023

-Hard Tissue Engineering; Principles and Applications, Authored by Faghihi S, Hosseini S and Mirzaeian F, ACECR Publication, Amirkabir University of Technology Branch, 2024

- Valouzi A, Taghiyar L, Baei P, Babaeizad A, Hosseini S, Sheykhhasan M, " Applications of fiber-based natural biomaterials in bone tissue engineering" in the book" Harnessing Fiber-Based Natural Biomaterials" Edited by Mohit Kumar, Manoj Kumar Singh, Sanjay Mavinkere Rangappa, Suchart Siengchin, Ajay Sharma, 2026, Elsevier.

- Baei P, Bagheri Azizabad Z, Araban S, Babaeizad A, Sheykhhasan M, Hosseini S " Applications of fiber-based natural biomaterials in cartilage tissue engineering" in the book" Harnessing Fiber-Based Natural Biomaterials" Edited by Mohit Kumar, Manoj Kumar Singh, Sanjay Mavinkere Rangappa, Suchart Siengchin, Ajay Sharma, 2026, Elsevier.

- Soleymani-Goloujeh M, Hosseini S, Baghaban Eslaminejad MR, "Advanced nanotechnology Approaches as Emerging Tools in Cellular-based Technologies" in the book" Advances in Experimental Medicine and Biology" Edited by Kursad Turksen, pp 127-144, 2023, Springer Cham.

- Hosseini S, Halvaei M, Ebrahimi A, Shamekhi MA, Baghaban Eslaminejad MR "3D-printing in Dentistry" in the book " Application of Biomedical Engineering in Dentistry " Edited by Lobat Tayebi, 2019, Springer (Humana Press).

 

A position for a talented and motivated Ph.D. student is open in my group.