Royan Stem Cell – Royan institute for Stem Cell Biology and Technology (RI-SCBT)

Leila Taghiyar Ph.D
Stem Cells and Developmental Biology
Assistant professor

Email:leilataghiyar@royaninstitute.org
Tel:1724
Fax:
CV:Taghiyar CV-2024.doc

Leila Taghiyar is a faculty member at the Royan Institute of Stem Cell Biology and Technology. She holds a Ph.D. in Developmental Biology from Royan Institute, where her research focused on stem cell differentiation into bone and cartilage, as well as digit tip regeneration in animals using transgenic cells. She has served as the principal investigator on numerous basic sciences, preclinical, and related clinical trials in the field of regenerative medicine. She served as the Editor-in-Chief of the journal Regeneration for 3 years, and also supervises the production of clonal mesenchymal stem cells as advanced therapy medicinal products at the Royan ATMP Center. Now, she is the CEO of Roein Tan Cell, a company specializing in the development of advanced cell, gene, and tissue-based medical therapies. Currently, the company offers five cell-based products designed to treat conditions such as rheumatoid arthritis (RA), low back pain (LBP), diabetic foot ulcers (DFU), and skin burns.

She firmly believes that achieving success in cell therapy depends on thorough and rigorous foundational research. Her research interests include: - Deriving mesenchymal stem cells from various tissues, such as bone marrow (in humans and small and large animals), adipose tissue, dental pulp, Wharton's Jelly, and Placenta tissues. - Basic study done on proliferation and differentiation of stem cells into bone, cartilage, and muscle lineages in both 2D and 3D cultures. - Bone and cartilage tissue engineering. - Regenerating the digit tip amputated. - Creating animal models for bone and cartilage-related diseases.

sadaf Lashgari

MSc Students

Samira Ramezani

MSc Students

Saghi Ghafarzadeh

MSc Students

Amir Ali Judaki

MSc Students

Alaleh Dehghan

MSc Students

Mehrnoush Kianpour

MSc Students

Amir Hossein Ghazanfari

MSc Students

Selva Vosoughi

MSc Students

1. Mohamadreza Baghaban Eslaminejad, Leila Taghiyar and Fatemeh Safari. Nano tissue Engineering of Musculoskeletal Cells, Stem-Cell Nanoengineering Book. 2 JAN 2015. 2. Hosseini S, Taghiyar L, Safari F, Baghaban Eslaminejad M. Regenerative Medicine Applications of Mesenchymal Stem Cells. Adv Exp Med Biol. 2018 May 17. 3. M Talebi Jouybari, N Fani, S Jahangir, F Bagheri, R Golru, L Taghiyar. Validation of Tissue-Engineered Constructs: Preclinical and Clinical Studies. Biology to Biofabrication, 2023. 491-527 4. Maryam Talebi Jouybari, Nesa Fani, Shahrbanoo Jahangir, Fatemeh Bagheri, Reihaneh Golru, and Leila Taghiyar. Validation of Tissue-Engineered Constructs: Preclinical and Clinical Studies 2023. 18. 981-99-2452-3 (eBook) https://doi.org/10.1007/978-981-99-2452-3. 5. Leila Taghiyar, Shahrbano Jahangir, Mojtaba Khozaei Ravari, Mohammad Amin Shamekhi, Mohamadreza Baghaban Eslaminejad. Cartilage Repair by Mesenchymal Stem Cell-Derived Exosomes: Preclinical and Clinical Trial Update and Perspectives. Adv Exp Med Biol doi: 10.1007/5584_2021_625. 6. Maryam Talebi Jouybari, Nesa Fani, Shahrbanoo Jahangir, Fatemeh Bagheri, Reihaneh Golru, and Leila Taghiyar. Validation of Tissue-Engineered Constructs: Preclinical and Clinical Studies. EditorsCartilage: From Biology to Biofabrication. Spiringer. 2024. 1. Mohamadreza Baghaban Eslaminejad, Aghbibi Nikmahzar , Leila Taghiyar , Samad Nadri ,Mohamad Massumi . Murine mesenchymal stem cells isolated by low density primary culture system.Develop. Growth Differ.2006; 48,361-370 2. Mohamadreza Baghaban Eslaminejad, Aghbibi Nikmahzar , Leila Taghiyar , Samad Nadri ,Mohamad Massumi . Murine mesenchymal stem cells isolated by low density primary culture System keep differentiation potential up to passage 10. Cell Reseach , 2006,16: S36-S37 3. Mohamadreza Baghaban Eslaminejad ,Leila Taghiyar. Equine Marrow-derived Mesenchymal stem cells: isolation, differentiation and culture optimization. Iranian J of Veterinary Research, shiraz University, Vol 10.No.1 Ser No.26,2006. Mohamadreza Baghaban Eslaminejad, Hamid nazarian ,Leila Taghiyar, Mesenchymal stem cell isolation from the removed medium of rats bone merrow primary culture and their differentiation into cell lineages, Yakhteh Medical Journal,Vol:10, No:1 Spring 2008 4. Mohamadreza Baghaban Eslaminejad ,Leila Taghiyar. Mesenchymal stem cells purification from the Articular Cartilage cell culture .Iranian J of Basic Medical Sciences.Vol:10,No:3, Autumn 2008,146-153 5. Mohamadreza Baghaban Eslaminejad, Fahimeh Falahi, Hamid nazarian ,Leila Taghiyar. Differentiation Potential and Culture Requirements of Mesenchymal Stem cells from Ovine Bone Marrow for Tissue Regenetation Applications. J of IJVS ,Vol. 2,No. 5, 2007 6. Mohamadreza Baghaban Eslaminejad ,Leila Taghiyar, Fahimeh Falahi. Costal versus articular chondrochtes in alginate three-dimensional cultures. Iranian Journal of Biotechnology , Vol. 7, No.3, 2009 7. Mohamadreza Baghaban Eslaminejad, Fahimeh Falahi, Hamid nazarian ,Leila Taghiyar. Ex vivo Expansion and Differentiation of Mesenchymal Stem Cells from Goat Bone Marrow. Iranian Journal of Basic Medical Sciences. Vol. 12, No.2, 2009. 8. Mohamadreza Baghaban Eslaminejad ,Leila Taghiyar, Fahimeh Falahi. Co-Culture of Mesenchymal stem cells with Mature Chondrochytes: Producing cartilage construct for Application in Cartilage Regeneration. Journal of IJMS. Vol. 34,No.4, 2009. 9. Mohamadreza Baghaban Eslaminejad ,Leila Taghiyar, Fahimeh Falahi. Quantitative Analysis of the Proliferation and Differentiation of Rat Articular Chondrocytes in Alginate 3D Culture. Iranian Journal of Biomedical . Vol. 13,No.3, 2009. 10. Mohsen Emadedin, Naser Aghdami, Leila Taghiyar, Roghayeh Fazeli, Reza Moghadasali, Shahrbanoo Jahangir, Reza Farjad, Mohamadreza Baghaban Eslaminejad. Intra-articular Injection of Autologous Mesenchymal Stem Cells in Six Patients with Knee Osteoarthritis. A clinical trial. Archives of Iranian Medicine, Volume 15, Number 7, July 2012. 11. Reza Fekrazad, Mohamadreza Baghban Eslaminejad, Arman M. Shayan, Katayoun A.M. Kalhori, Fatemeh Mashhadi Abbas, Leila Taghiyar, Mir SepehrPedram, Mostafa Sadeghi Ghuchani. Effects of Photobiomodulation and Mesenchymal Stem Cells on Articular Cartilage Defects in a Rabbit Model. Photomedicine and Laser Surgery Volume X, Number X, 2016. 12. Fekrazad R, Sadeghi Ghuchani M, Eslaminejad MB, Taghiyar L, Kalhori KA, Pedram MS, Shayan AM, Aghdami N, Abrahamse H. The effects of combined low level laser therapy and mesenchymal stem cells on bone regeneration in rabbit calvarial defects. J Photochem Photobiol B. 151:180-5, 2015. 13. Leila Taghiyar, Samaneh Hosseini, Mahdi Hesaraki, Forough Azam Sayahpour, Nasser Aghdami, Mohamadreza Baghaban Eslaminejad. Isolation, Characterization and Osteogenic Potential of Mouse Digit Tip Blastema Cells in Comparison with Bone Marrow-derived Mesenchymal Stem Cells in vitro. Cell Journal (Yakhteh). Volume 19, Number 4, 2018, Serial Number: 76. 2017. 14. Leila Taghiyar, Mahdi Hesaraki, Forough Azam Sayahpour, Leila Satarian, Samaneh Hosseini, Naser Aghdami, Mohamadreza Baghaban Eslaminejad. Msh homeobox 1 (Msx1)− and Msx2−overexpressing bone marrow−derived mesenchymal stem cells resemble blastema cells and enhance regeneration in mice. JBC Journal, 2017. 15. Taghiyar L, Hosseini S, Safari F, Bagheri F, Fani N, Stoddart MJ, Alini M, Eslaminejad MB. New insight into functional limb regeneration: A to Z approaches. J Tissue Eng Regen Med. 2018 Sep;12(9):1925-1943. 16. Fatemeh Haghwerdi, Mojtaba Khozaei Ravari, Leila Taghiyar, Mohammad Amin Shamekhi, Shahrbano Jahangir, Ismaeil Haririan, Mohamadreza Baghaban Eslaminejad. Application of bone and cartilage extracellular matrices in articular cartilage regeneration. Biomed Mater. 2021 Jun 28;16 (4). 17. Mojtaba Khozaei Ravari, Shohreh Mashayekhan, Fatemeh Zarei, Forough Azam Sayyahpour, Leila Taghiyar, Mohamadreza Baghban Eslaminejad. Fabrication and characterization of an injectable reinforced composite scaffold for cartilage tissue engineering: an in vitro study. Biomed Mater. 2021 Mar 30;16(4):045007. 18. Mohammad Pakzad, Seyedeh Nafiseh Hassani, Fatemeh Abbasi, Ensiyeh Hajizadeh-Saffar, Leila Taghiyar, Nasrin Fallah, Newsha Haghparas, Azam Samadian, Meysam Ganjibakhsh, Massimo Dominic, Hossein Baharvand A Roadmap for the Production of a GMP-Compatible Cell Bank of Allogeneic Bone Marrow-Derived Clonal Mesenchymal Stromal Cells for Cell Therapy Applications. Stem Cell Rev Rep. 2022;18(7):2279-2295. 19. Fatemeh Bijarchian, Leila Taghiyar, Zahra Azhdari, Mohamadreza Baghaban Eslaminejad. M2c Macrophages enhance phalange regeneration of amputated mice digits in an organ co-culture system. 2022 Iranian Journal of Basic Medical Sciences, Volume 24, Issue 11. 20. Mahshad Mohseni, Parvin Shokrollahi, Fatemeh Shokrolahi, Samaneh Hosseini, Leila Taghiyar, Amir Kamali. Dexamethasone-loaded injectable, self-healing hydrogel microspheres based on UPy-functionalized Gelatin/ZnHAp physical network promotes bone regeneration. International Journal of Pharmaceutics Volume 626, 15 October 2022, 122196. 21. Leila Taghiyar, Hamideh Asadi, Mohamadreza Baghaban Eslaminejad. A bioscaffold of a decellularized whole osteochondral sheet improves proliferation and differentiation of loaded mesenchymal stem cells in a rabbit model. Cell Tissue Bank. 2023 Mar 20. 22. Morteza Zarrabi, Mohammad Amin Shahrbaf, Masoumeh Nouri, Faezeh Shekari, Seyedeh-Esmat Hosseini, Seyed-Mohammad Reza Hashemian, Rasoul Aliannejad, Hamidreza Jamaati, Naghmeh Khavandgar, Hediyeh Alemi, Hoda Madani, Abdoreza Nazari, Azadeh Amini, Seyedeh Nafiseh Hassani, Fatemeh Abbasi, Neda Jarooghi, Nasrin Fallah, Leila Taghiyar, Meysam Ganjibakhsh, Ensiyeh Hajizadeh-Saffar, Massoud Vosough, Hossein Baharvand. Allogenic mesenchymal stromal cells and their extracellular vesicles in COVID-19 induced ARDS: a randomized controlled trial. Stem Cell Res Ther. 2023 Jun 26;14(1):169. 23. Maryam Faeed, Mahsa Ghiasvand, Bahar Fareghzadeh and Leila Taghiyar. Osteochondral organoids: current advances, applications, and upcoming challenges. Stem Cell Research & Therapy (2024) 15:183. 24. Zarei F, Shafaghi R, Dehghan M, Mostafaee F, Taghiyar L, Eslaminejad MR. The Best Autologous Cell Sources for Articular Cartilage Regeneration with Critical Size Defects in an Ovine Knee Joints Model. Cell and Tissue Journal 14(4) (2023) 353-372. 25. Maryam Talebi Jouybari, Fatemeh Mojtahedi, Mahnaz Babaahmadi, Maryam Faeed, Mohammadreza Baghaban Eslaminejad and Leila Taghiyar. Advancements in extracellular vesicle targeted therapies for rheumatoid arthritis: insights into cellular origins, current perspectives, and emerging challenges. Stem Cell Research & Therapy (2024) 15:276. 26. Maryam Talebi Jouybari, Leila Taghiyar. Approaches of Mesenchymal Stem Cells Derived-Extracellular Vesicles in Knee Osteoarthritis Defects. J Mazandaran Univ Med Sci 2024; 33 (230): 160-178. 27. Maryam Talebi Jouybari1, Fatemeh Mojtahedi, Mahnaz Babaahmadi, Maryam Faeed, Mohammadreza Baghaban Eslaminejad, Leila Taghiyar. Correction: Advancements in extracellular vesicle targeted therapies for rheumatoid arthritis: insights into cellular origins, current perspectives, and emerging challenges. Jouybari et al. Stem Cell Research & Therapy (2024) 15:405. 28. Maryam Faeed, Mahsa Ghiasvand, Bahar Fareghzadeh and Leila Taghiyar. Osteochondral organoids: current advances applications, and upcoming challenges. Stem Cell Research & Therapy (2024) 15:183. 29. Samaneh Adhami, Mahsa Sheikhan, Rouhollah Fathi, Mohammadreza Zamanian, Abdolhossein Shaverdi, Parvaneh Afsharian, Hossein Baharvand, Leila Taghiyar, Leila Satarian. Exploring advances in reproduction and stem cell biology: highlights from the 24th and 19th international congresses in Iran. 2024/6/1. Cell Journal (Yakhteh). 30. Ahmadreza Jamshidi, Alireza Beheshti Maal, Majid Alikhani, Hoda Madani, Bahareh Sadri, Maryam Moghaddassi, Ahmad Salimzadeh, Mahtab Ahmadipour, Mohammad Amin Shahrbaf, Ensiyeh Hajizadeh-Saffar, Mohamadreza Baghaban Eslaminejad, Seyedeh-Nafiseh Hassani, Leila Taghiyar, Fatemeh Abbasi, Hossein Baharvand & Massoud Vosough. Allogeneic bone marrow-derived clonal mesenchymal stromal cells in refractory rheumatoid arthritis: a pilot study. Regenerative Medicine, Dec 2024. 31. Sahar Shemshadi, Faezeh Shekari, Mohamadreza Baghaban Eslaminejad, Leila Taghiyar. Extracellular vesicles derived from Msh homeobox 1 (Msx1)-overexpressing mesenchymal stem cells improve digit tip regeneration in an amputee mice model. Sci Rep, 2024 Oct 9;14(1):23538.

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She currently has an open position for a PhD student.